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Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients

Authors :
Andreas Keller
Nicole Ludwig
Tobias Fehlmann
Mustafa Kahraman
Christina Backes
Fabian Kern
Claus F. Vogelmeier
Caroline Diener
Ulrike Fischer
Frank Biertz
Christian Herr
Rudolf A. Jörres
Hans-Peter Lenhof
Robert Bals
Eckart Meese
Source :
Cells, Vol 8, Iss 10, p 1162 (2019)
Publication Year :
2019
Publisher :
MDPI AG, 2019.

Abstract

Chronic obstructive pulmonary disease (COPD) is associated with an increased risk of death, reducing life expectancy on average between 5 and 7 years. The survival time after diagnosis, however, varies considerably as a result of the heterogeneity of COPD. Therefore, markers that predict individual survival of COPD patients are of great value. We analyzed baseline molecular profiles and collected 54 months of follow-up data of the cohort study “COPD and SYstemic consequences-COmorbidities NETwork” (COSYCONET). Genome-wide microRNA signatures from whole blood collected at time of the inclusion in the study were generated for 533 COPD patients including patients that deceased during the 54-month follow-up period (n = 53) and patients that survived this period (n = 480). We identified two blood-born microRNAs (miR-150-5p and miR-320b) that were highly predictive for survival of COPD patients. The expression change was then confirmed by RT-qPCR in 245 individuals. Ninety percent of patients with highest expression of miR-150-5p survived the 54-month period in contrast to only 50% of patients with lowest expression intensity. Moreover, the abundance of the oncogenic miR-150-5p in blood of COPD patients was predictive for the development of cancer. Thus, molecular profiles measured at the time of a COPD diagnosis have a high predictive power for the survival of patients.

Details

Language :
English
ISSN :
20734409
Volume :
8
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Cells
Publication Type :
Academic Journal
Accession number :
edsdoj.09b38aa81f9401085f00ca677862d3f
Document Type :
article
Full Text :
https://doi.org/10.3390/cells8101162