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Chinese herbal medicine compound of flavonoids adjunctive treatment for oral cancer

Authors :
Yi-Chao Huang
Min-Yi Sung
Tsung-Kun Lin
Chan-Yen Kuo
Yi-Chiung Hsu
Source :
Journal of the Formosan Medical Association, Vol 123, Iss 8, Pp 830-836 (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Oral cancer is a prevalent global issue, with oral squamous cell carcinoma constituting the majority of cases. Standard treatments like surgery, radiotherapy, and chemotherapy are available but may have adverse effects. Molecular gene therapy, focusing on genetic mutations linked to oral cancer, presents a promising alternative.In this study, we evaluated 27 chemotherapeutic drugs and 63 Chinese herbal medicines for their effectiveness, categorized them by their cellular mechanisms, and identified potential adjuvant therapy candidates for oral cancer. Our findings highlight the impact of natural flavonoids on oral cancer cells, inducing apoptosis, and confirming their potential in molecular genetic analysis. In conclusion, the natural compounds present in Chinese herbal medicine, particularly flavonoids, offer a promising avenue to target specific genetic mutations in oral cancer cells. This approach may reduce the risks associated with oral cancer treatment and pave the way for innovative adjuvant therapies.

Details

Language :
English
ISSN :
09296646
Volume :
123
Issue :
8
Database :
Directory of Open Access Journals
Journal :
Journal of the Formosan Medical Association
Publication Type :
Academic Journal
Accession number :
edsdoj.09aa6e4ba894adb889f5e78e83954ac
Document Type :
article
Full Text :
https://doi.org/10.1016/j.jfma.2023.10.009