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Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism

Authors :
Michael Landowski
Vijesh J. Bhute
Samuel Grindel
Zachary Haugstad
Yeboah K. Gyening
Madison Tytanic
Richard S. Brush
Lucas J. Moyer
David W. Nelson
Christopher R. Davis
Chi-Liang Eric Yen
Sakae Ikeda
Martin-Paul Agbaga
Akihiro Ikeda
Source :
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Lipid analysis of transmembrane protein 135 (TMEM135) mutant mice reveals robust decreases in docosahexaenoic acid (DHA), indicating a function of TMEM135 on the export of DHA from peroxisomes that is important for maintaining lipid metabolism.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
6
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.097ba34414892882b668cb0412247
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-022-04404-7