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Corneal injury repair and the potential involvement of ZEB1
- Source :
- Eye and Vision, Vol 11, Iss 1, Pp 1-15 (2024)
- Publication Year :
- 2024
- Publisher :
- BMC, 2024.
-
Abstract
- Abstract The cornea, consisting of three cellular and two non-cellular layers, is the outermost part of the eyeball and frequently injured by external physical, chemical, and microbial insults. The epithelial-to-mesenchymal transition (EMT) plays a crucial role in the repair of corneal injuries. Zinc finger E-box binding homeobox 1 (ZEB1), an important transcription factor involved in EMT, is expressed in the corneal tissues. It regulates cell activities like migration, transformation, and proliferation, and thereby affects tissue inflammation, fibrosis, tumor metastasis, and necrosis by mediating various major signaling pathways, including transforming growth factor (TGF)-β. Dysfunction of ZEB1 would impair corneal tissue repair leading to epithelial healing delay, interstitial fibrosis, neovascularization, and squamous cell metaplasia. Understanding the mechanism underlying ZEB1 regulation of corneal injury repair will help us to formulate a therapeutic approach to enhance corneal injury repair.
- Subjects :
- ZEB1
EMT
Corneal damage
Inflammation
Neovascularization
Scarring
Ophthalmology
RE1-994
Subjects
Details
- Language :
- English
- ISSN :
- 23260254
- Volume :
- 11
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Eye and Vision
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.09742ad938e4cd39728c2f0c8e2696e
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s40662-024-00387-0