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Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly

Authors :
Chuchu Wang
Jia Tu
Shengnan Zhang
Bin Cai
Zhenying Liu
Shouqiao Hou
Qinglu Zhong
Xiao Hu
Wenbin Liu
Guohui Li
Zhijun Liu
Lin He
Jiajie Diao
Zheng-Jiang Zhu
Dan Li
Cong Liu
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Vesicle associated membrane protein 2 (VAMP2) contains a conserved SNARE motif that interacts with syntaxin-1 and SNAP25 for SNARE complex assembly. Here authors use in-cell NMR spectroscopy to describe the dynamic membrane association of VAMP2 SNARE motif in mammalian cells at the atomic resolution.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.0967f87a5aae4500b37410d2f85f412c
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-15270-4