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Immunoglobulin E-Dependent Activation of Immune Cells in Rhinovirus-Induced Asthma Exacerbation
- Source :
- Frontiers in Allergy, Vol 3 (2022)
- Publication Year :
- 2022
- Publisher :
- Frontiers Media S.A., 2022.
-
Abstract
- Acute exacerbation is the major cause of asthma morbidity, mortality, and health-care costs. Respiratory viral infections, particularly rhinovirus (RV) infections, are associated with the majority of asthma exacerbations. The risk for bronchoconstriction with RV is associated with allergic sensitization and type 2 airway inflammation. The efficacy of the humanized anti-IgE monoclonal antibody omalizumab in treating asthma and reducing the frequency and severity of RV-induced asthma exacerbation is well-known. Despite these clinical data, mechanistic details of omalizumab's effects on RV-induced asthma exacerbation have not been well-defined for years due to the lack of appropriate animal models. In this Perspective, we discuss potential IgE-dependent roles of mast cells and dendritic cells in asthma exacerbations.
Details
- Language :
- English
- ISSN :
- 26736101
- Volume :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Frontiers in Allergy
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.095f13e64ca483686fd293d5cb11510
- Document Type :
- article
- Full Text :
- https://doi.org/10.3389/falgy.2022.835748