Prenylcysteine oxidase 1, an emerging player in atherosclerosis

Authors :: C. Banfi
R. Baetta
S. S. Barbieri
M. Brioschi
A. Guarino
S. Ghilardi
L. Sandrini
S. Eligini
G. Polvani
O. Bergman
P. Eriksson
E. Tremoli
Source :: Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Publication Year :: 2021
Publisher :: Nature Portfolio, 2021.
Abstract: Banfi et al. investigate the role of Prenylcysteine oxidase 1 (PCYOX1), an enzyme implicated in catabolism of prenylated cysteine, in human and murine atherosclerosis. They find that loss of PCYOX1 is anti-atherogenic and understanding its biology and functions can potentially provide significant therapeutic opportunities in addressing atherosclerosis.