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Protein ubiquitination in ovarian cancer immunotherapy: The progress and therapeutic strategy

Authors :
Huiling Guo
Jianwei Wei
Yuyan Zhang
Li Wang
Junhu Wan
Weiwei Wang
Ling Gao
Jiajing Li
Ting Sun
Liwei Ma
Source :
Genes and Diseases, Vol 11, Iss 6, Pp 101158- (2024)
Publication Year :
2024
Publisher :
KeAi Communications Co., Ltd., 2024.

Abstract

Ovarian cancer is a common cancer for females, and the incidence and mortality rates are on the rise. Many treatment strategies have been developed for ovarian cancer, including chemotherapy and immunotherapy, but they are often ineffective and prone to drug resistance. Protein ubiquitination is an important class of post-translation modifications that have been found to be associated with various human diseases and cancer development. Recent studies have revealed that protein ubiquitination is involved in the progression of ovarian cancer and plays an important role in the tumor immune process. Moreover, the combination of ubiquitinase/deubiquitinase inhibitors and cancer immunotherapy approaches can effectively reduce treatment resistance and improve treatment efficacy, which provides new ideas for cancer treatment. Herein, we review the role of protein ubiquitination in relation to ovarian cancer immunotherapy and recent advances in the use of ubiquitinase/deubiquitinase inhibitors in combination with cancer immunotherapy.

Details

Language :
English
ISSN :
23523042
Volume :
11
Issue :
6
Database :
Directory of Open Access Journals
Journal :
Genes and Diseases
Publication Type :
Academic Journal
Accession number :
edsdoj.0929691ff514d34a2726d21bc39c804
Document Type :
article
Full Text :
https://doi.org/10.1016/j.gendis.2023.101158