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Whole genome sequencing reveals hidden transmission of carbapenemase-producing Enterobacterales

Authors :
Kalisvar Marimuthu
Indumathi Venkatachalam
Vanessa Koh
Stephan Harbarth
Eli Perencevich
Benjamin Pei Zhi Cherng
Raymond Kok Choon Fong
Surinder Kaur Pada
Say Tat Ooi
Nares Smitasin
Koh Cheng Thoon
Paul Anantharajah Tambyah
Li Yang Hsu
Tse Hsien Koh
Partha Pratim De
Thean Yen Tan
Douglas Chan
Rama Narayana Deepak
Nancy Wen Sim Tee
Andrea Kwa
Yiying Cai
Yik-Ying Teo
Natascha May Thevasagayam
Sai Rama Sridatta Prakki
Weizhen Xu
Wei Xin Khong
David Henderson
Nicole Stoesser
David W. Eyre
Derrick Crook
Michelle Ang
Raymond Tzer Pin Lin
Angela Chow
Alex R. Cook
Jeanette Teo
Oon Tek Ng
Carbapenemase-Producing Enterobacteriaceae in Singapore (CaPES) Study Group
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Carbapenemase-producing Enterobacterales cause healthcare-associated infections but modes of transmission are not well understood. Here, the authors find evidence of transmission without direct patient contact, indicating presence of undetected environmental reservoirs, whilst half of the transmission events are likely due to plasmid-mediated transmission.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.09070082885140fca1ec2bec5614e8c2
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-30637-5