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Precise control of SCRaMbLE in synthetic haploid and diploid yeast

Authors :
Bin Jia
Yi Wu
Bing-Zhi Li
Leslie A. Mitchell
Hong Liu
Shuo Pan
Juan Wang
Hao-Ran Zhang
Nan Jia
Bo Li
Michael Shen
Ze-Xiong Xie
Duo Liu
Ying-Xiu Cao
Xia Li
Xiao Zhou
Hao Qi
Jef D. Boeke
Ying-Jin Yuan
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

The SCRaMbLE system integrated into Sc2.0’s synthetic yeast chromosome project allows rapid strain evolution. Here the authors use a genetic logic gate to control induction of recombination in a haploid and diploid yeast carrying synthetic chromosomes.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.08f2e5c10a842a095d6c577d5999efa
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-03084-4