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Ginsenoside-Rp1 inhibits radiation-induced effects in lipopolysaccharide-stimulated J774A.1 macrophages and suppresses phenotypic variation in CT26 colon cancer cells
- Source :
- Journal of Ginseng Research, Vol 44, Iss 6, Pp 843-848 (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- This study investigated the inhibitory effect of ginsenoside-Rp1 (G-Rp1) on the ionizing radiation (IR)-induced response in lipopolysaccharide (LPS)-stimulated macrophages and its effects on the malignancy of tumor cells. G-Rp1 inhibited the activation of IR-induced DNA damage-related signaling molecules and thereby interfered with the IR-increased production of nitric oxide (NO) and interleukin (IL)-1β. The inhibitory effect of G-Rp1 increased the survival rate of mice inoculated with CT26 colon cancer cells by suppressing the phenotypic variation of tumor cells induced by conditioned medium obtained from IR- and LPS-treated J774A.1 macrophages.
- Subjects :
- Cancer
Ginsenoside-Rp1
Macrophages
Panax ginseng
Radiation
Botany
QK1-989
Subjects
Details
- Language :
- English
- ISSN :
- 12268453
- Volume :
- 44
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Ginseng Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.08ce7651c4704a7a85ea92a466be0da6
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jgr.2020.01.006