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Potentiometric and Blood Plasma Simulation Studies of Nickel(II) Complexes of Poly(amino)amido Pentadentate Ligands: Computer Aided Metal-Based Drug Design

Authors :
Sebusi Odisitse
Graham E. Jackson
Source :
Bioinorganic Chemistry and Applications, Vol 2014 (2014)
Publication Year :
2014
Publisher :
Hindawi Limited, 2014.

Abstract

The thermodynamic equilibria of nickel(II) with N,N′-di(aminoethylene)-2,6-pyridinedicarbonylamine (L1), Bis-(N,N-dimethylethyl)-2,6-pyridinedicarboxamide (L2), and N,N′-bis[2(2-pyridyl)-methyl]pyridine-2,6-dicarboxamide (L3) have been studied at 25°C and an ionic strength of 0.15 mol dm−3 by glass electrode potentiometry. The protonation and formation constants added to blood plasma model predict that Cu(II) competes effectively against Ni(II), Zn(II), and Ca(II) for these ligands in vivo.

Details

Language :
English
ISSN :
15653633 and 1687479X
Volume :
2014
Database :
Directory of Open Access Journals
Journal :
Bioinorganic Chemistry and Applications
Publication Type :
Academic Journal
Accession number :
edsdoj.08a718c220ae4167a5f35709c47bc1e5
Document Type :
article
Full Text :
https://doi.org/10.1155/2014/863612