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Potentiometric and Blood Plasma Simulation Studies of Nickel(II) Complexes of Poly(amino)amido Pentadentate Ligands: Computer Aided Metal-Based Drug Design
- Source :
- Bioinorganic Chemistry and Applications, Vol 2014 (2014)
- Publication Year :
- 2014
- Publisher :
- Hindawi Limited, 2014.
-
Abstract
- The thermodynamic equilibria of nickel(II) with N,N′-di(aminoethylene)-2,6-pyridinedicarbonylamine (L1), Bis-(N,N-dimethylethyl)-2,6-pyridinedicarboxamide (L2), and N,N′-bis[2(2-pyridyl)-methyl]pyridine-2,6-dicarboxamide (L3) have been studied at 25°C and an ionic strength of 0.15 mol dm−3 by glass electrode potentiometry. The protonation and formation constants added to blood plasma model predict that Cu(II) competes effectively against Ni(II), Zn(II), and Ca(II) for these ligands in vivo.
- Subjects :
- Biotechnology
TP248.13-248.65
Inorganic chemistry
QD146-197
Subjects
Details
- Language :
- English
- ISSN :
- 15653633 and 1687479X
- Volume :
- 2014
- Database :
- Directory of Open Access Journals
- Journal :
- Bioinorganic Chemistry and Applications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.08a718c220ae4167a5f35709c47bc1e5
- Document Type :
- article
- Full Text :
- https://doi.org/10.1155/2014/863612