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Dysregulated plasma glucagon levels in Japanese young adult type 1 diabetes patients
- Source :
- Journal of Diabetes Investigation, Vol 10, Iss 1, Pp 62-66 (2019)
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Abstract Currently, the clinical dynamics of glucagon need to be revised based on previous data obtained from conventional glucagon radioimmunoassays. In the present study, we evaluated plasma glucagon levels in type 1 diabetes patients using a newly‐developed sandwich enzyme‐linked immunosorbent assay, and its association with clinical parameters and markers of diabetes complications were statistically assessed. The plasma glucagon level in 77 Japanese type 1 diabetes patients was 28.1 ± 17.7 pg/mL, and comparable with that reported previously for type 2 diabetes patients. However, the values were widely spread and did not correlate with plasma glucose values. Additionally, the average glucagon levels in patients in a hypoglycemic state (glucose level
Details
- Language :
- English
- ISSN :
- 20401124 and 20401116
- Volume :
- 10
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Diabetes Investigation
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.08909b7e3894479a80bbc1eacab7eeb1
- Document Type :
- article
- Full Text :
- https://doi.org/10.1111/jdi.12862