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A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative

Authors :
Changkuo Zhao
Xianheng Wang
Fuhong Yang
Lei Gao
Yuhe Wang
Source :
Royal Society Open Science, Vol 5, Iss 2 (2018)
Publication Year :
2018
Publisher :
The Royal Society, 2018.

Abstract

A facile synthetic method was developed for a novel acid-sensitive camptothecin norcantharidin acid ester derivative I. The total yield can reach 71%. This method provides several advantages, including high yield and simple working procedure for the synthesis of analogues. The new synthetic compound I has been shown to exhibit better solubility and similar activity against tumour cell lines.

Details

Language :
English
ISSN :
20545703
Volume :
5
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Royal Society Open Science
Publication Type :
Academic Journal
Accession number :
edsdoj.087f15514f1249cd835f4d596132f9d6
Document Type :
article
Full Text :
https://doi.org/10.1098/rsos.170842