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A simple route to a novel acid-sensitive 20(S)-O-linked camptothecin norcantharidin acid ester derivative
- Source :
- Royal Society Open Science, Vol 5, Iss 2 (2018)
- Publication Year :
- 2018
- Publisher :
- The Royal Society, 2018.
-
Abstract
- A facile synthetic method was developed for a novel acid-sensitive camptothecin norcantharidin acid ester derivative I. The total yield can reach 71%. This method provides several advantages, including high yield and simple working procedure for the synthesis of analogues. The new synthetic compound I has been shown to exhibit better solubility and similar activity against tumour cell lines.
- Subjects :
- camptothecin
norcantharidin
synthesis
water solubility
tumour
Science
Subjects
Details
- Language :
- English
- ISSN :
- 20545703
- Volume :
- 5
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Royal Society Open Science
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.087f15514f1249cd835f4d596132f9d6
- Document Type :
- article
- Full Text :
- https://doi.org/10.1098/rsos.170842