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Protection against Oxidative Stress and Metabolic Alterations by Synthetic Peptides Derived from Erythrina edulis Seed Protein

Authors :
Nathaly Rodríguez-Arana
Karim Jiménez-Aliaga
Arturo Intiquilla
José A. León
Eduardo Flores
Amparo Iris Zavaleta
Víctor Izaguirre
Christian Solis-Calero
Blanca Hernández-Ledesma
Source :
Antioxidants, Vol 11, Iss 11, p 2101 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

The ability of multifunctional food-derived peptides to act on different body targets make them promising alternatives in the prevention/management of chronic disorders. The potential of Erythrina edulis (pajuro) protein as a source of multifunctional peptides was proven. Fourteen selected synthetic peptides identified in an alcalase hydrolyzate from pajuro protein showed in vitro antioxidant, anti-hypertensive, anti-diabetic, and/or anti-obesity effects. The radical scavenging properties of the peptides could be responsible for the potent protective effects observed against the oxidative damage caused by FeSO4 in neuroblastoma cells. Moreover, their affinity towards the binding cavity of angiotensin-converting enzyme (ACE) and dipeptidyl peptidase IV (DPP-IV) were predicted by molecular modeling. The results demonstrated that some peptides such as YPSY exhibited promising binding at both enzymes, supporting the role of pajuro protein as a novel ingredient of functional foods or nutraceuticals for prevention/management of oxidative stress, hypertension, and metabolic-alteration-associated chronic diseases.

Details

Language :
English
ISSN :
20763921
Volume :
11
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Antioxidants
Publication Type :
Academic Journal
Accession number :
edsdoj.0862a4697d8446ca8256b7bb28144a85
Document Type :
article
Full Text :
https://doi.org/10.3390/antiox11112101