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Insights into COVID-19 and Its Potential Implications for Kidney Dysfunction

Authors :
Adel Abdel-Moneim
Eman H. Bakry
Mohamed Y. Zaky
Source :
International Journal of Translational Medicine, Vol 3, Iss 2, Pp 255-273 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a significant impact on the world’s demographics, resulting in over 6 million deaths globally. COVID-19 has been associated with a variety of disease manifestations in various organ systems, including kidney disease, in addition to pulmonary manifestations. Infection with SARS-CoV-2 can not only cause new kidney damage but also make treatment and care more difficult, as well as increase mortality in people who already have kidney problems. COVID-19 is indeed associated with a variety of renal pathologies, such as acute tubular necrosis, proteinuria, hematuria, and thrombosis complications. Cytokine storms, hypoxemia, direct viral invasion via angiotensin-converting enzyme 2 and cathepsin L, electrolyte imbalance, and fever are among the pathophysiological mechanisms underlying these clinical symptoms. Over the last two years, many COVID-19 vaccines have been discovered. However, there have been a few case reports of AKI, AKD, proteinuria, edema, gross hematuria, and other renal side effects that necessitated hospitalization after receiving COVID-19 vaccinations. Thus, the current review aimed to evaluate COVID-19-induced kidney dysfunction in terms of clinical features, pathogenesis, long-term outcomes, and vaccine harms based on the most up-to-date findings.

Details

Language :
English
ISSN :
26738937
Volume :
3
Issue :
2
Database :
Directory of Open Access Journals
Journal :
International Journal of Translational Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.0840e7e729b9472891d56877c438ec01
Document Type :
article
Full Text :
https://doi.org/10.3390/ijtm3020018