Chemical proteomics tracks virus entry and uncovers NCAM1 as Zika virus receptor

Authors :: Mayank Srivastava
Ying Zhang
Jian Chen
Devika Sirohi
Andrew Miller
Yang Zhang
Zhilu Chen
Haojie Lu
Jianqing Xu
Richard J. Kuhn
W. Andy Tao
Source :: Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Publication Year :: 2020
Publisher :: Nature Portfolio, 2020.
Abstract: The mechanism underlying the cellular entry of Zika virus is not fully understood. Here, the authors use a chemically modified virus and time-resolved proteomics to capture interacting host proteins during virus entry and identify NCAM1 as a ZIKV receptor.

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