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Emerging Role and Mechanism of circRNAs in Pediatric Malignant Solid Tumors

Authors :
Qiyang Shen
Xingyu Liu
Wei Li
Xu Zhao
Tao Li
Kai Zhou
Jianfeng Zhou
Source :
Frontiers in Genetics, Vol 12 (2022)
Publication Year :
2022
Publisher :
Frontiers Media S.A., 2022.

Abstract

Circular RNAs (circRNAs) are non-coding RNAs with covalent closed-loop structures and are widely distributed in eukaryotes, conserved and stable as well as tissue-specific. Malignant solid tumors pose a serious health risk to children and are one of the leading causes of pediatric mortality. Studies have shown that circRNAs play an important regulatory role in the development of childhood malignant solid tumors, hence are potential biomarkers and therapeutic targets for tumors. This paper reviews the biological characteristics and functions of circRNAs as well as the research progress related to childhood malignant solid tumors.

Details

Language :
English
ISSN :
16648021
Volume :
12
Database :
Directory of Open Access Journals
Journal :
Frontiers in Genetics
Publication Type :
Academic Journal
Accession number :
edsdoj.080aaa8aab634aeeaba3379e137e95f8
Document Type :
article
Full Text :
https://doi.org/10.3389/fgene.2021.820936