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The Counter-Regulation of Atherogenesis: a Role for Interleukin-33
- Source :
- Acta Medica, Vol 53, Iss 3, Pp 125-129 (2010)
- Publication Year :
- 2010
- Publisher :
- Karolinum Press, 2010.
-
Abstract
- The recently recognized cytokine interleukin-33 and its receptor ST2 play a favorable role during atherogenesis by inducing a Th1→Th2 shift of the immune response. IL-33 also protects the failing human heart from harmful biomechanical forces which lead to cardiomyocyte hypertrophy and exaggerated interstitial fibrosis. IL-33 inevitably displays side effects common to other Th2 cytokines, the most grave of which is a predisposition to allergic reactions. IL-33 is a nuclear transcription factor of endothelial cells. As such, it is abundant in nonproliferating vessels. Its down-regulation is required for angiogenesis, which may be profitable in wound healing or deleterious in tumor growth.
Details
- Language :
- English
- ISSN :
- 18059694 and 12114286
- Volume :
- 53
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Acta Medica
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.07fedbba628b47f48936de66b106a0c2
- Document Type :
- article
- Full Text :
- https://doi.org/10.14712/18059694.2016.71