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Improvement of Antarctic krill oil on reserpine induced zebrafish depression model
- Source :
- Shipin yu jixie, Vol 39, Iss 7, Pp 152-156,171 (2023)
- Publication Year :
- 2023
- Publisher :
- ZHU Beiwei, 2023.
-
Abstract
- Objective: This study aimed to investigate the effect of Antarctic krill oil on zebrafish model of depression. Methods: The zebrafish (Danio rerio) model of depression was induced by 40 mg/L reserpine, and five groups, i.e., blank control group, model group, fluoxetine group, low-dose krill oil group and high-dose krill oil group were investigated and compared, buy using new tank test (NTT) and light dark box test (LDB). The central nervous system serotonin (5-HT), dopamine (DA), monoamine oxidase A (MAO-A) Interleukin-6 (IL-6), tumor necrosis factor α (TNF-α) and systemic cortisol (COR) levels of the five groups were analyzed. Results: Reserpine 40 mg/L caused depressive behavior in zebrafish, while the addition of prawn oil reduced the this behavior, by increasing the levels of monoamine neurotransmitters including 5-HT and DA in the brain and decreasing the levels of MAO-A, IL-6 and TNF-α proinflammatory factors and systemic COR levels. Conclusion: Antarctic krill oil can improve the depression of zebrafish by reducing neuroinflammation and regulating neuroendocrine.
Details
- Language :
- English, Chinese
- ISSN :
- 10035788
- Volume :
- 39
- Issue :
- 7
- Database :
- Directory of Open Access Journals
- Journal :
- Shipin yu jixie
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.07b9af16a9ba4065abb160e321e6968c
- Document Type :
- article
- Full Text :
- https://doi.org/10.13652/j.spjx.1003.5788.2022.81050