Back to Search Start Over

The Actin Network Interfacing Diverse Integrin-Mediated Adhesions

Authors :
Benjamin Geiger
Rajaa Boujemaa-Paterski
Sabina E. Winograd-Katz
Jubina Balan Venghateri
Wen-Lu Chung
Ohad Medalia
Source :
Biomolecules, Vol 13, Iss 2, p 294 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

The interface between the cellular actin network and diverse forms of integrin-mediated cell adhesions displays a unique capacity to serve as accurate chemical and mechanical sensors of the cell’s microenvironment. Focal adhesion-like structures of diverse cell types, podosomes in osteoclasts, and invadopodia of invading cancer cells display distinct morphologies and apparent functions. Yet, all three share a similar composition and mode of coupling between a protrusive structure (the lamellipodium, the core actin bundle of the podosome, and the invadopodia protrusion, respectively), and a nearby adhesion site. Cytoskeletal or external forces, applied to the adhesion sites, trigger a cascade of unfolding and activation of key adhesome components (e.g., talin, vinculin, integrin), which in turn, trigger the assembly of adhesion sites and generation of adhesion-mediated signals that affect cell behavior and fate. The structural and molecular mechanisms underlying the dynamic crosstalk between the actin cytoskeleton and the adhesome network are discussed.

Details

Language :
English
ISSN :
2218273X
Volume :
13
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Biomolecules
Publication Type :
Academic Journal
Accession number :
edsdoj.0781232aab44299d0c2b946af226c4
Document Type :
article
Full Text :
https://doi.org/10.3390/biom13020294