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Comparison of the Whole-Genome Sequence of the African Swine Fever Virus from a Mongolian Wild Boar with Genotype II Viruses from Asia and Europe

Authors :
Ulaankhuu Ankhanbaatar
Agathe Auer
Gerelmaa Ulziibat
Tirumala B. K. Settypalli
Delgerzul Gombo-Ochir
Ganzorig Basan
Taichiro Takemura
Erdene-Ochir Tseren-Ochir
Hatem Ouled Ahmed
Irene Kasindi Meki
Sneha Datta
Baba Soumare
Artem Metlin
Giovanni Cattoli
Charles E. Lamien
Source :
Pathogens, Vol 12, Iss 9, p 1143 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

African swine fever (ASF) is a highly contagious and severe viral hemorrhagic disease in domestic and wild pigs. ASF seriously affects the global swine industry as the mortality rate can reach 100% with highly virulent strains. In 2007, ASF was introduced into the Caucasus and spread to Russia and later into other European and Asian countries. This study reported the first whole-genome sequence (WGS) of the ASF virus (ASFV) that was detected in a Mongolian wild boar. This sequence was then compared to other WGS samples from Asia and Europe. Results show that the ASFV Genotype II from Mongolia is similar to the Asian Genotype II WGS. However, there were three nucleotide differences found between the Asian and European genome sequences, two of which were non-synonymous. It was also observed that the European Genotype II ASFV WGS was more diverse than that of the Asian counterparts. The study demonstrates that the ASFV Genotype II variants found in wild boars and domestic pigs are highly similar, suggesting these animals might have had direct or indirect contact, potentially through outdoor animal breeding. In conclusion, this study provides a WGS and mutation spectrum of the ASFV Genotype II WGS in Asia and Europe and thus provides important insights into the origin and spread of ASFV in Mongolia.

Details

Language :
English
ISSN :
20760817
Volume :
12
Issue :
9
Database :
Directory of Open Access Journals
Journal :
Pathogens
Publication Type :
Academic Journal
Accession number :
edsdoj.07673a7573564d27aa4d5d49abf79cc6
Document Type :
article
Full Text :
https://doi.org/10.3390/pathogens12091143