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LETR1 is a lymphatic endothelial-specific lncRNA governing cell proliferation and migration through KLF4 and SEMA3C

Authors :
Luca Ducoli
Saumya Agrawal
Eliane Sibler
Tsukasa Kouno
Carlotta Tacconi
Chung-Chao Hon
Simone D. Berger
Daniela Müllhaupt
Yuliang He
Jihye Kim
Marco D’Addio
Lothar C. Dieterich
Piero Carninci
Michiel J. L. de Hoon
Jay W. Shin
Michael Detmar
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Long noncoding RNAs regulate tissue-specific gene expression. Here the authors profile lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs) and show a role of LEC-specific lncRNA, LETR1, in cell proliferation and migration.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.0736dd382c0449a084d82843bda88f5a
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-21217-0