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Effects of Psychostimulant Drugs on Developing Brain

Effects of Psychostimulant Drugs on Developing Brain

Authors :
Ibrahim Durukan
Murat Erdem
Koray Kara
Dursun Karaman
Source :
Psikiyatride Güncel Yaklaşımlar, Vol 5, Iss 4, Pp 528-539 (2013)
Publication Year :
2013
Publisher :
Psikiyatride Güncel Yaklaşımlar, 2013.

Abstract

Although psychostimulants have been used for the treatment of attention deficit hyperactivity disorder for approximately 70 years, little is known about the long term effects of these drugs on developing brain. The observable effects of psychostimulants are influenced by the timing of exposure, the age of examination after drug exposure and sex. Preclinical studies point out that chronic psychostimulant exposure before adolescence cause reverse sensitization or tolerance and this leads to reduction in stimulant effectiveness in adolesecence and adulthood. Preclinical studies show the potential long term effects of psychostimulants. But it is necessary to investigate the relationship between preclinical effects and clinical practice. A developmental approach is needed to understand the impact of pediatric medications on the brain that includes assessment at multiple ages to completely characterize the long term effects of these medications. The aim of this paper is to review the effects of psychostimulants on developing brain.

Details

Language :
English, Turkish
ISSN :
13090658
Volume :
5
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Psikiyatride Güncel Yaklaşımlar
Publication Type :
Academic Journal
Accession number :
edsdoj.071403497fad425c81de5551a73f864b
Document Type :
article
Full Text :
https://doi.org/10.5455/cap.20130532