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Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus

Authors :
David Stacey
Lingyan Chen
Paulina J. Stanczyk
Joanna M. M. Howson
Amy M. Mason
Stephen Burgess
Stephen MacDonald
Jonathan Langdown
Harriett McKinney
Kate Downes
Neda Farahi
James E. Peters
Saonli Basu
James S. Pankow
Weihong Tang
Nathan Pankratz
Maria Sabater-Lleal
Paul S. de Vries
Nicholas L. Smith
CHARGE Hemostasis Working Group
Amy D. Gelinas
Daniel J. Schneider
Nebojsa Janjic
Nilesh J. Samani
Shu Ye
Charlotte Summers
Edwin R. Chilvers
John Danesh
Dirk S. Paul
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Many individual genetic risk loci associate with multiple diseases, but the molecular basis of these loci often remains unclear. Here, the authors provide a framework to reveal the genetic cross-disease associations at the PROCR vascular disease locus.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.06e0764427f642ea9f1647a016e4fe9d
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-28729-3