Back to Search Start Over

OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gαz

Authors :
Alastair C. Keen
Maria Hauge Pedersen
Laura Lemel
Daniel J. Scott
Meritxell Canals
Dene R. Littler
Travis Beddoe
Yuki Ono
Lei Shi
Asuka Inoue
Jonathan A. Javitch
J. Robert Lane
Source :
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

A recently identified pertussis toxin-like AB5 toxin, OZITX, is found to inhibit Gαi/o and Gαz G proteins. In combination with directed mutations, it is a useful tool for interrogating Gαi/o/z G protein subunits individually.

Subjects

Subjects :
Biology (General)
QH301-705.5

Details

Language :
English
ISSN :
23993642
Volume :
5
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.065c0033244eb3932a5b3f91103777
Document Type :
article
Full Text :
https://doi.org/10.1038/s42003-022-03191-5