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Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals

Authors :
Prokopis C. Prokopiou
Nina Engels-Domínguez
Kathryn V. Papp
Matthew R. Scott
Aaron P. Schultz
Christoph Schneider
Michelle E. Farrell
Rachel F. Buckley
Yakeel T. Quiroz
Georges El Fakhri
Dorene M. Rentz
Reisa A. Sperling
Keith A. Johnson
Heidi I. L. Jacobs
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Older individuals exhibiting diminished function of the locus coeruleus while learning new information show faster cognitive decline that is typical for Alzheimer’s disease.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.064e0e4a05864dea8910777843fb04ad
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-28986-2