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Histological and Immunohistochemical Characteristics for Hereditary Breast Cancer Risk in a Cohort of Brazilian Women

Authors :
Renata Mendes de Freitas
Maximiliano Ribeiro Guerra
Vívian Assis Fayer
Angélica Atala Lombelo Campos
Jane Rocha Duarte Cintra
Joan Warren
Rafaela Russi Ervilha
Camila Damasceno de Paula
Maria Teresa Bustamante-Teixeira
Source :
Revista Brasileira de Ginecologia e Obstetrícia, Vol 44, Iss 8, Pp 761-770 (2022)
Publication Year :
2022
Publisher :
Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 2022.

Abstract

Abstract Objective The study aimed to characterize the clinical, histological, and immunohistochemical profile of women with invasive breast cancer, according to the risk for Hereditary Predisposition Breast and Ovarian Cancer Syndrome in a Brazilian population. Methods This is a retrospective study performed from a hospital-based cohort of 522 women, diagnosed with breast cancer treated at an oncology referral center in the Southeast region of Brazil, between 2014 and 2016. Results Among the 430 women diagnosed with invasive breast cancer who composed the study population, 127 (29.5%) were classified as at increased risk for hereditary predisposition to breast and ovarian cancer syndrome. There was a lower level of education in patients at increased risk (34.6%) when compared with those at usual risk (46.0%). Regarding tumor characteristics, women at increased risk had higher percentages of the disease diagnosed at an advanced stage (32.3%), and with tumors > 2cm (63.0%), with increased prevalence for both characteristics, when compared with those at usual risk. Furthermore, we found higher percentages of HG3 (43.3%) and Ki-67 ≥ 25% (64.6%) in women at increased risk, with prevalence being about twice as high in this group. The presence of triple-negative tumors was observed as 25.2% in women at increased risk and 6.0% in women at usual risk, with the prevalence of absence of biomarkers being 2.5 times higher among women in the increased risk group. Conclusion From the clinical criteria routinely used in the diagnosis of breast cancer, the care practice of genetic counseling for patients at increased risk of hereditary breast cancer in contexts such as Brazil is still scarce.

Details

Language :
English, Portuguese
ISSN :
01007203
Volume :
44
Issue :
8
Database :
Directory of Open Access Journals
Journal :
Revista Brasileira de Ginecologia e Obstetrícia
Publication Type :
Academic Journal
Accession number :
edsdoj.05fdb821b9f143f5ab19b2b25b7ab21a
Document Type :
article
Full Text :
https://doi.org/10.1055/s-0042-1743103