Ocular Complications in Adults with Sickle Cell Disease in Lagos – A Comparative Study

Introduction: Sickle cell disease has been associated with ocular complications in several studies. However, it has not often been compared with nonhemoglobinopathy controls. Aim: The aim of this study was to determine the ocular complications of sickle cell disease patients compared with controls in Lagos. Study Design: This was an open-label comparative study. Materials and Methods: Consecutive consenting confirmed sickle cell disease patients with hemoglobin SS and hemoglobin SC (HbSS and HbSC) were recruited, as were age- and sex-matched hemoglobin AA (HbAA) (non-HbSS/HbSC) controls. All had genotype screened, interviewed, and examined. Systemic comorbidities (diabetes, hypertension, human immunodeficiency virus, etc.) were excluded. P