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A genome-wide association study for allergen component sensitizations identifies allergen component–specific and allergen protein group–specific associations
- Source :
- Journal of Allergy and Clinical Immunology: Global, Vol 2, Iss 2, Pp 100086- (2023)
- Publication Year :
- 2023
- Publisher :
- Elsevier, 2023.
-
Abstract
- Background: Allergic diseases are some of the most common diseases worldwide. Genome-wide association studies (GWASs) have been conducted to elucidate the genetic factors of allergic diseases. However, no GWASs for allergen component sensitization have been performed. Objective: We sought to detect genetic variants associated with differences in immune responsiveness against allergen components. Methods: The participants of the present study were recruited from the Tokyo Children’s Health, Illness, and Development study, and allergen component–specific IgE level at age 9 years was measured by means of allergen microarray immunoassays. We performed GWASs for allergen component sensitization against each allergen (single allergen component sensitization, number of allergen components analyzed, n = 31), as well as against allergen protein families (allergen protein group sensitization, number of protein groups analyzed, n = 16). Results: We performed GWAS on 564 participants of the Tokyo Children’s Health, Illness, and Development study and found associations between Amb a 1 sensitization and the immunoglobulin heavy-chain variable gene on chromosome 14 and between Phl p 1 sensitization and the HLA class II region on chromosome 6 (P < 5.0 × 10−8). A GWAS-significant association was also observed between the HLA class II region and profilin sensitization (P < 5.0 × 10−8). Conclusions: Our data provide the first demonstration of genetic risk for allergen component sensitization and show that this genetic risk is related to immune response genes including immunoglobulin heavy-chain variable gene and HLA.
Details
- Language :
- English
- ISSN :
- 27728293
- Volume :
- 2
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Allergy and Clinical Immunology: Global
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.058964c6d2e64335bbff19fe91a7e2b9
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.jacig.2023.100086