Back to Search
Start Over
Endoscopic mucosal resection using anchored snare Tip-in versus precut technique for small rectal neuroendocrine tumors
- Source :
- The Korean Journal of Internal Medicine, Vol 39, Iss 2, Pp 238-247 (2024)
- Publication Year :
- 2024
- Publisher :
- The Korean Association of Internal Medicine, 2024.
-
Abstract
- Background/Aims Small rectal neuroendocrine tumors (NETs) can be treated with modified endoscopic mucosal resection (EMR). However, an optimal EMR method remains to be established. We aimed to assess the non-inferiority of Tip-in EMR versus precut EMR (EMR-P) for treating rectal NETs. Methods This prospective, multicenter, randomized controlled trial enrolled patients with rectal NETs of < 10 mm in diameter. The patients were randomly assigned to EMR-P and Tip-in EMR groups in a 1:1 ratio. Primary outcome was margin-negative (R0) resection rate between the two methods, with a noninferiority margin of 10%. Results Seventy-five NETs in 73 patients, including 64 eligible lesions (32 lesions in each, EMR-P and Tip-in EMR groups), were evaluated. In a modified intention-to-treat analysis, R0 resection rates of the EMR-P and Tip-in EMR groups were 96.9% and 90.6%, respectively, which did not demonstrate non-inferiority (risk difference, −6.3 [95% confidence interval: −18.0 to 5.5]). Resection time in the EMR-P group was longer than that in the Tip-in EMR group (p < 0.001). One case of intraprocedural bleeding was reported in each group. Conclusions We did not demonstrate the non-inferiority of Tip-in EMR compared to EMR-P for treating small rectal NETs. However, the R0 resection rates for both techniques were high enough for clinical application.
Details
- Language :
- English
- ISSN :
- 12263303 and 20056648
- Volume :
- 39
- Issue :
- 2
- Database :
- Directory of Open Access Journals
- Journal :
- The Korean Journal of Internal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.058387fd96fc48fd91d09e41acc25415
- Document Type :
- article
- Full Text :
- https://doi.org/10.3904/kjim.2023.263