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A robust brain network for sustained attention from adolescence to adulthood that predicts later substance use

Authors :
Yihe Weng
Johann Kruschwitz
Laura M Rueda-Delgado
Kathy L Ruddy
Rory Boyle
Luisa Franzen
Emin Serin
Tochukwu Nweze
Jamie Hanson
Alannah Smyth
Tom Farnan
Tobias Banaschewski
Arun LW Bokde
Sylvane Desrivières
Herta Flor
Antoine Grigis
Hugh Garavan
Penny A Gowland
Andreas Heinz
Rüdiger Brühl
Jean-Luc Martinot
Marie-Laure Paillère Martinot
Eric Artiges
Jane McGrath
Frauke Nees
Dimitri Papadopoulos Orfanos
Tomas Paus
Luise Poustka
Nathalie Holz
Juliane Fröhner
Michael N Smolka
Nilakshi Vaidya
Gunter Schumann
Henrik Walter
Robert Whelan
IMAGEN Consortium
Source :
eLife, Vol 13 (2024)
Publication Year :
2024
Publisher :
eLife Sciences Publications Ltd, 2024.

Abstract

Substance use, including cigarettes and cannabis, is associated with poorer sustained attention in late adolescence and early adulthood. Previous studies were predominantly cross-sectional or under-powered and could not indicate if impairment in sustained attention was a predictor of substance use or a marker of the inclination to engage in such behavior. This study explored the relationship between sustained attention and substance use across a longitudinal span from ages 14 to 23 in over 1000 participants. Behaviors and brain connectivity associated with diminished sustained attention at age 14 predicted subsequent increases in cannabis and cigarette smoking, establishing sustained attention as a robust biomarker for vulnerability to substance use. Individual differences in network strength relevant to sustained attention were preserved across developmental stages and sustained attention networks generalized to participants in an external dataset. In summary, brain networks of sustained attention are robust, consistent, and able to predict aspects of later substance use.

Details

Language :
English
ISSN :
2050084X
Volume :
13
Database :
Directory of Open Access Journals
Journal :
eLife
Publication Type :
Academic Journal
Accession number :
edsdoj.05771362878447809c1ed97878f3e707
Document Type :
article
Full Text :
https://doi.org/10.7554/eLife.97150