Scientific Knowledge Graph and Trend Analysis of Central Sensitization: A Bibliometric Analysis

Zhuo Li,1,2,* Chi Xu,2,* Jun Fu,2 Maimaiti Zulipikaer,2 Tao Deng,2 Jiying Chen2 1School of Medicine, Nankai University, Tianjin, People’s Republic of China; 2Department of Orthopedic Surgery, Chinese PLA General Hospital, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiying Chen, Department of Orthopedic Surgery, Chinese PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing, 100853, People’s Republic of China, Tel +86 10 66938104, Fax +86 10 68216336, Email jiyingchen_301@163.comBackground: Central sensitization refers to a state of hypersensitivity in the central nervous system and is associated with the development and maintenance of chronic pain. Central sensitization plays an essential role in various diseases. Nevertheless, there has been no bibliometric analysis before in this field. The purpose of this study was to provide critical themes and trends in the area of central sensitization, to build a network of knowledge, and to facilitate the future development of relevant basic and clinical research.Methods: Publications on central sensitization were extracted from the Science Citation Index-Expanded. We used R software to systematically analyze the countries, institutions, authors, journals, references, and keywords of the publications. Besides, conceptual structure, intellectual structure, and social structure were constructed.Results: A total of 4466 publications were included. Research in the field of central sensitization generally showed a steady upward trend. The three structural networks showed that the United States is the leading country in this field. Arendt-Nielsen L and Woolf CJ were the most productive and influential authors, respectively. “Pain” was the journal with the most studies. Most journals that published and cited articles about central sensitization were academically influential. Cluster analysis revealed that research in central sensitization contains three main conceptual clusters, and the themes of research evolve frequently. Current research focuses on the pathogenesis of central sensitization in neuropathic pain, the role of central sensitization in different diseases, and related clinical double-blind trials.Conclusion: Central sensitization received widespread attention. The United States led the way in academic activity. In this field, the current situation of cooperation and communication between different countries and institutions is positive. The present research hotspots were the pathogenesis of central sensitization in neuropathic pain, the role of central sensitization in different diseases, and related clinical double-blind trials.Keywords: central sensitization, bibliometric analysis, pain, co-word, co-citation, collaboration network