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An Effective Synthesis of Previously Unknown 7-Aryl Substituted Paullones

Authors :
Dmitrii A. Aksenov
Alesia S. Akulova
Elena A. Aleksandrova
Nicolai A. Aksenov
Alexander V. Leontiev
Alexander V. Aksenov
Source :
Molecules, Vol 28, Iss 5, p 2324 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

A straightforward three-step procedure affording a wide range of novel 7-aryl substituted paullone derivatives was developed. This scaffold is structurally similar to 2-(1H-indol-3-yl)acetamides—promising antitumor agents—hence, could be useful for the development of a new class of anticancer drugs.

Subjects

Subjects :
Fisher indolization
paullones synthesis
anticancer drug discovery
Organic chemistry
QD241-441

Details

Language :
English
ISSN :
14203049
Volume :
28
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
edsdoj.05631df6850f4c2d8d25c5e5659639d4
Document Type :
article
Full Text :
https://doi.org/10.3390/molecules28052324
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