Raphia australis: Acute toxicity, antioxidant capacity and antihypertensive effect in spontaneously hypertensive rats

Background & Aim: The fruits of R. australis are eaten as snacks in some West and Central African countries. This study was aimed at evaluating the safety, antioxidant capacity and antihypertensive effects of these fruits. Experimental: The acute toxicity of the extract of R. australis extract (RAE) was evaluated through single and short term oral exposure of mice to RAE. Total phenols and flavonoid contents were quantified followed by 1,1‑diphenyl‑2‑picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. Spontaneously hypertensive rats (SHR) were treated with RAE and blood pressure (BP) was measured after once off treatment (phase I) and in the course of 4 weeks treatment (phase II). Results: The LD50 of RAE was greater than 5000 mg/kg. RAE had mild antioxidant capacity and significantly (P