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Bone marrow-derived mesenchymal stem cells attenuate myocardial ischemia–reperfusion injury via upregulation of splenic regulatory T cells

Authors :
Ling-Xiao Pang
Wen-Wei Cai
Qian Li
Heng-Jie Li
Min Fei
Yong-Sheng Yuan
Bin Sheng
Ke Zhang
Rong-Cheng An
Ying-Wei Ou
Wen-Jie Zeng
Source :
BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-12 (2021)
Publication Year :
2021
Publisher :
BMC, 2021.

Abstract

Abstract Background Myocardial ischemia–reperfusion injury (MIRI) is the main pathological manifestation of cardiovascular diseases such as myocardial infarction. The potential therapeutic effects of bone marrow-derived mesenchymal stem cells (BM-MSCs) and the participation of regulatory T cells (Tregs) in MIRI remains to be defined. Methods We used the experimental acute MIRI that was induced in mice by left ascending coronary ischemia, which were subsequently randomized to receive immunoglobulin G (IgG) or anti-CD25 antibody PC61 with or without intravenously injected BM-MSCs. The splenectomized mice underwent prior to experimental MIRI followed by intravenous administration of BM-MSCs. At 72 h post-MIRI, the hearts and spleens were harvested and subjected to cytometric and histologic analyses. Results CD25+Foxp3+ regulatory T cells were significantly elevated after MIRI in the hearts and spleens of mice receiving IgG + BM-MSCs and PC61 + BM-MSCs compared to the respective control mice (all p

Details

Language :
English
ISSN :
14712261
Volume :
21
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Cardiovascular Disorders
Publication Type :
Academic Journal
Accession number :
edsdoj.0551a9b7a6fd479a803ed8b783274948
Document Type :
article
Full Text :
https://doi.org/10.1186/s12872-021-02007-4