Brain status modeling with non-negative projective dictionary learning

Accurate prediction of individuals’ brain age is critical to establish a baseline for normal brain development. This study proposes to model brain development with a novel non-negative projective dictionary learning (NPDL) approach, which learns a discriminative representation of multi-modal neuroimaging data for predicting brain age. Our approach encodes the variability of subjects in different age groups using separate dictionaries, projecting features into a low-dimensional manifold such that information is preserved only for the corresponding age group. The proposed framework improves upon previous discriminative dictionary learning methods by incorporating orthogonality and non-negativity constraints, which remove representation redundancy and perform implicit feature selection. We study brain development on multi-modal brain imaging data from the PING dataset (N = 841, age = 3−21 years). The proposed analysis uses our NDPL framework to predict the age of subjects based on cortical measures from T1-weighted MRI and connectome from diffusion weighted imaging (DWI). We also investigate the association between age prediction and cognition, and study the influence of gender on prediction accuracy. Experimental results demonstrate the usefulness of NDPL for modeling brain development.