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Proteins from SARS-CoV-2 reduce T cell proliferation: A mirror image of sepsis
- Source :
- Heliyon, Vol 6, Iss 12, Pp e05635- (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Increased cytokine levels, acute phase reactants and immune checkpoint expression changes have been described in patients with Coronavirus Disease 2019 (COVID-19). Here, we have reported a monocyte polarization towards a low HLA-DR and high PD-L1 expression after long exposure to proteins from SARS-CoV-2. Moreover, CD86 expression was also reduced over SARS-CoV-2 proteins exposure. Additionally, T-cells proliferation was significantly reduced after stimulation with these proteins. Eventually, patients with long-term SARS-CoV-2 infection also exhibited a significant blockade of T-cells proliferation.
Details
- Language :
- English
- ISSN :
- 24058440
- Volume :
- 6
- Issue :
- 12
- Database :
- Directory of Open Access Journals
- Journal :
- Heliyon
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.04cbda20deb548639e400a6b2fa2aab2
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.heliyon.2020.e05635