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A Comprehensive Overview of the Past, Current, and Future Randomized Controlled Trials in Hepatic Encephalopathy

Authors :
Ovidiu-Dumitru Ilie
Raluca Duta
Ilinca-Bianca Nita
Irina Dobrin
Irina-Luciana Gurzu
Irina Girleanu
Laura Huiban
Cristina Muzica
Alin Ciobica
Roxana Popescu
Petru Cianga
Carol Stanciu
Diana Cimpoesu
Anca Trifan
Source :
Medicina, Vol 59, Iss 12, p 2143 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Background: Hepatic encephalopathy (HE) caused by cirrhosis has severe consequences on an individual’s lifespan, leading to long-term liver complications and potentially life-threatening outcomes. Despite recent interest in this condition, the effectiveness of secondary prophylaxis involving rixafimin, lactulose, or L-ornithine L-aspartate (LOLA) may be hindered by the unique microbial profiles each patient possesses. Methods: Thus, in this manuscript, we aimed to search, identify, and gather all randomized controlled trials (RCTs) published between 2000–2023 (November) in four major academic databases such as PubMed, ISI Web of Science, Scopus, and ScienceDirect by using a controlled terminology and web strings that reunite six main keywords. We complementarily retrieved data on the ongoing RCTs. Results: Regardless of the relatively high number of results displayed (n = 75), 46.66% (n = 35) were initially deemed eligible after the first evaluation phase after removing duplicates, n = 40 (53.34%). At the second assessment stage, we eliminated 11.42% (n = 4) studies, of which n = 22 finally met the eligibility criteria to be included in the main body of the manuscript. In terms of RCTs, otherwise found in distinct stages of development, n = 3 target FMT and n = 1 probiotics. Conclusions: Although we benefit from the necessary information and technology to design novel strategies for microbiota, only probiotics and synbiotics have been extensively studied in the last decade compared to FMT.

Details

Language :
English
ISSN :
16489144 and 1010660X
Volume :
59
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Medicina
Publication Type :
Academic Journal
Accession number :
edsdoj.0484a61a90c14a198798c987bcd1abe8
Document Type :
article
Full Text :
https://doi.org/10.3390/medicina59122143