Mild cognitive decline in type 2 diabetes mellitus patients – risk factors and pathogenesis: role of DPP4 activity and future possible therapeutic targets

Owais Gul,1 Saqib Gul2 1Department of Medicine, Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan; 2Department of Medicine, Hamdard University, Karachi, PakistanWe read with great interest, the recently published article “Risk factors for developing dementia in type 2 diabetes mellitus patients with mild cognitive impairment” by Albai et al.1 The article provided a great insight into evaluating the prevalence of mild cognitive impairment (MCI) in patients with type 2 diabetes (T2DM) and highlighted the risk factors for conversion of MCI to dementia. We would like to add some knowledge of the mechanisms and pathogenesis of the development of MCI in T2DM patients and a guide to possible future therapeutic developments.View the original paper by Albai and colleagues.