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Investigation on a Sensitive Chemiluminescence System Based on Ni(IV) Complex to Determine Two β2-Agonist Drugs in Urine and Swine Feed and Their Mechanism

Authors :
Xiao Dong
Yajie Diao
Xinghua Li
Tingting Dai
Hongmei Shi
Shan Li
Source :
Applied Sciences, Vol 8, Iss 5, p 663 (2018)
Publication Year :
2018
Publisher :
MDPI AG, 2018.

Abstract

Veterinary drug residues, particularly traces of β2-agonists, can cause various kinds of harmful impact to the environment and public health. Here, a sensitive chemiluminescence (CL) method incorporated with a flow injection analysis is developed for the determination of two β2-agonists [i.e., salbutamol (SAL) and terbutaline (TEB)]. The system is based on the CL reaction of Ni(IV) complex with luminol in alkaline solutions, whereas SAL and TEB can significantly enhance CL intensities. Under optimum conditions, CL intensities are proportional to the SAL and TEB concentration in the range of 1.0 × 10−9 M to 5.0 × 10−7 M and 1.0 × 10−9 M to 1.0 × 10−7 M, respectively. The limits of detection (3σ) are 1.0 × 10−11 M for TEB, and 1.3 × 10−11 for SAL respectively. Relative standard deviations (n = 11) are less than 2% for 5.0 × 10−8 M SAL and TEB. Possible reaction mechanisms for the CL system are suggested based on the CL system spectra, Ni(IV) complex oxidation characteristics, and electron spin resonance (ESR) techniques. The proposed method has been applied to the analysis of urine and swine feed samples with satisfactory results.

Details

Language :
English
ISSN :
20763417
Volume :
8
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Applied Sciences
Publication Type :
Academic Journal
Accession number :
edsdoj.040b58c7c9f04c72a69397cbf18aea76
Document Type :
article
Full Text :
https://doi.org/10.3390/app8050663