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Multi-stage bioengineering of a layered oesophagus with in vitro expanded muscle and epithelial adult progenitors

Authors :
Luca Urbani
Carlotta Camilli
Demetra-Ellie Phylactopoulos
Claire Crowley
Dipa Natarajan
Federico Scottoni
Panayiotis Maghsoudlou
Conor J. McCann
Alessandro Filippo Pellegata
Anna Urciuolo
Koichi Deguchi
Sahira Khalaf
Salvatore Ferdinando Aruta
Maria Cristina Signorelli
David Kiely
Edward Hannon
Matteo Trevisan
Rui Rachel Wong
Marc Olivier Baradez
Dale Moulding
Alex Virasami
Asllan Gjinovci
Stavros Loukogeorgakis
Sara Mantero
Nikhil Thapar
Neil Sebire
Simon Eaton
Mark Lowdell
Giulio Cossu
Paola Bonfanti
Paolo De Coppi
Source :
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Publication Year :
2018
Publisher :
Nature Portfolio, 2018.

Abstract

Combining decellularised scaffolds with patient-derived cells holds promise for bioengineering of functional tissues. Here the authors develop a two-stage approach to engineer an oesophageal graft that retains the structural organisation of native oesophagus.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
9
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.04035db7e1a6472b9d4fc0a2bd25b51a
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-018-06385-w