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Molecular Imaging to Identify Tumor Recurrence following Chemoradiation in a Hostile Surgical Environment

Authors :
Olugbenga T. Okusanya
Charuhas Deshpande
Eduardo M. Barbosa
Charu Aggarwal
Charles B. Simone
Jack Jiang
Ryan Judy
Elizabeth DeJesus
Steve Albelda
Shuming Nie
Philip S. Low
Sunil Singhal
Source :
Molecular Imaging, Vol 14 (2015)
Publication Year :
2015
Publisher :
SAGE Publishing, 2015.

Abstract

Surgical biopsy of potential tumor recurrence is a common challenge facing oncologists, surgeons, and cancer patients. Imaging modalities have limited ability to accurately detect recurrent cancer in fields affected by previous surgery, chemotherapy, or radiation. However, definitive tissue diagnosis is often needed to initiate treatment and to direct therapy. We sought to determine if a targeted fluorescent intraoperative molecular imaging technique could be applied in a clinical setting to assist a surgical biopsy in a “hostile” field. We describe the use of a folate-fluorescein conjugate to direct the biopsy of a suspected recurrent lung adenocarcinoma invading the mediastinum that had been previously treated with chemoradiation. We found that intraoperative imaging allowed the identification of small viable tumor deposits that were otherwise indistinguishable from scar and necrosis. Our operative observations were confirmed by histology, fluorescence microscopy, and immunohistochemistry. Our results demonstrate one possible application and clinical value of intraoperative molecular imaging.

Details

Language :
English
ISSN :
15360121
Volume :
14
Database :
Directory of Open Access Journals
Journal :
Molecular Imaging
Publication Type :
Academic Journal
Accession number :
edsdoj.03c71ad321ad40989173b15a99b787a2
Document Type :
article
Full Text :
https://doi.org/10.2310/7290.2014.00051