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Analysis of Factors Influencing Whole Blood Hydroxychloroquine Concentration in Patients with Systemic Lupus Erythematosus in China
- Source :
- Rheumatology and Therapy, Vol 10, Iss 6, Pp 1597-1607 (2023)
- Publication Year :
- 2023
- Publisher :
- Adis, Springer Healthcare, 2023.
-
Abstract
- Abstract Introduction The aim of this study was to determine the factors associated with the concentrations of hydroxychloroquine (HCQ) and its major metabolite, desethylhydroxychloroquine (DHCQ), in patients with systemic lupus erythematosus (SLE). Methods Patients with SLE taking oral HCQ for at least 3 months were recruited from the Department of Rheumatology and Immunology of Nanjing Drum Tower Hospital. Clinical characteristics and laboratory values were examined. The concentrations of HCQ and DHCQ were measured by high-performance liquid chromatography, and the effects of various factors on the concentrations were investigated. Results A total of 272 patients were included in this study. The average concentration of HCQ was 690.90 ng/ml and the average concentration of DHCQ was 431.84 ng/ml. Multivariate analysis indicated that gender (P = 0.015), age (year) (P
Details
- Language :
- English
- ISSN :
- 21986576 and 21986584
- Volume :
- 10
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Rheumatology and Therapy
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.039e18ed6a431a85d6c7abcd665c43
- Document Type :
- article
- Full Text :
- https://doi.org/10.1007/s40744-023-00598-2