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Single-center study on clinicopathological and typical molecular pathologic features of metastatic brain tumor

Authors :
Su Hwa Kim
Young Suk Lee
Sung Hak Lee
Yeoun Eun Sung
Ahwon Lee
Jun Kang
Jae-Sung Park
Sin Soo Jeun
Youn Soo Lee
Source :
Journal of Pathology and Translational Medicine, Vol 57, Iss 4, Pp 217-231 (2023)
Publication Year :
2023
Publisher :
Korean Society of Pathologists & the Korean Society for Cytopathology, 2023.

Abstract

Background The metastatic brain tumor is the most common brain tumor. The aim of this study was to demonstrate the clinicopathological and molecular pathologic features of brain metastases (BM). Methods A total of 269 patients were diagnosed with BM through surgical resection at Seoul St. Mary’s Hospital from January 2010 to March 2020. We reviewed the clinicopathological features and molecular status of primary and metastatic brain tissues using immunohistochemistry and molecular pathology results. Results Among 269 patients, 139 males and 130 females were included. The median age of primary tumor was 58 years (range, 13 to 87 years) and 86 patients (32.0%) had BM at initial presentation. Median BM free interval was 28.0 months (range, 1 to 286 months). The most frequent primary site was lung 46.5% (125/269), and followed by breast 15.6% (42/269), colorectum 10.0% (27/269). Epidermal growth factor receptor (EGFR) mutation was found in 50.8% (32/63) and 58.0% (40/69) of lung primary and BM, respectively. In both breast primary and breast cancer with BM, luminal B was the most frequent subtype at 37.9% (11/29) and 42.9% (18/42), respectively, followed by human epidermal growth factor receptor 2 with 31.0% (9/29) and 33.3% (14/42). Triple-negative was 20.7% (6/29) and 16.7% (7/42), and luminal A was 10.3% (3/29) and 7.1% (3/42) of breast primary and BM, respectively. In colorectal primary and colorectal cancer with BM, KRAS mutation was found in 76.9% (10/13) and 66.7% (2/3), respectively. Conclusions We report the clinicopathological and molecular pathologic features of BM that can provide useful information for understanding the pathogenesis of metastasis and for clinical trials based on the tumor’s molecular pathology.

Details

Language :
English, Korean
ISSN :
23837837, 23837845, and 03743586
Volume :
57
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Journal of Pathology and Translational Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.03743586937b4bd4ad434afca5ed0dc6
Document Type :
article
Full Text :
https://doi.org/10.4132/jptm.2023.06.10