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miR-let-7a inhibits sympathetic nerve remodeling after myocardial infarction by downregulating the expression of nerve growth factor
- Source :
- Open Medicine, Vol 19, Iss 1, Pp ii14-8 (2024)
- Publication Year :
- 2024
- Publisher :
- De Gruyter, 2024.
-
Abstract
- Sympathetic hyperinnervation following myocardial infarction (MI) is one of the primary causes of ventricular arrhythmias (VAs) after MI. Nerve growth factor (NGF) is a key molecule that induces sympathetic nerve remodeling. Previous studies have confirmed that microRNA (miR)-let-7a interacts with NGF. However, whether miR-let-7a is involved in sympathetic remodeling after MI remains unknown. We aimed to investigate whether miR-let-7a was associated with the occurrence of VA after MI.
Details
- Language :
- English
- ISSN :
- 23915463
- Volume :
- 19
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Open Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.034cfd7c2f6d4396b59aa056a267668d
- Document Type :
- article
- Full Text :
- https://doi.org/10.1515/med-2024-0975