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Clinical outcomes of the first 300 cases of kidney transplantation: a single-center retrospective cohort study
- Source :
- Korean Journal of Transplantation, Vol 34, Iss 3, Pp 154-166 (2020)
- Publication Year :
- 2020
- Publisher :
- Korean Society for Transplantation, 2020.
-
Abstract
- Background : Kidney transplantation (KT) is regarded as the most effective treatment for end-stage renal disease. The annual number of KT cases in South Korea has increased rapidly as more centers are implementing a transplantation program. The objective of this study was to determine clinical outcomes of the first 300 consecutive cases of KT in a single center. Methods : Clinical data of 300 cases of KT at Seoul National University Bundang Hospital from January 2004 to March 2018 were obtained from a prospectively collected database and retrospectively reviewed. Results : The mean age of patients was 47.7±12.9 years, and 59% of patients were male. There were 225 living donors and 75 deceased donors. A total of 42 cases were from ABO-incompatible donors. During a mean follow-up of 68.6±43.5 months, 38 patients (12.7%) experienced rejection. The most common cause was acute T-cell mediated rejection (9.0%). Eighteen patients experienced graft loss. One-year and 5-year death-censored graft survival rates were 99% and 96.6%, respectively. One-year and 5-year patient survival rates were 98.3% and 96.6%, respectively. Multivariate analysis revealed that graft weight-to-recipient weight ratio and rejection were significant factors affecting graft survival. Conclusions: This single-center review demonstrates clinical outcomes comparable to other major centers. Such good outcomes were obtained by good patient selection, dedicated transplant physicians, and adequate use of immunosuppressive therapy.
- Subjects :
- transplantation
kidney transplantation
Medical technology
R855-855.5
Subjects
Details
- Language :
- English
- ISSN :
- 26718790
- Volume :
- 34
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Korean Journal of Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0345450a32ec4efbba15884960cb48a3
- Document Type :
- article
- Full Text :
- https://doi.org/10.4285/kjt.2020.34.3.154