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Short-term effects of antimicrobial stewardship programs on antibiotics usage, clinical outcomes, and multidrug resistant organisms in the post COVID-19 era

Authors :
Rania Tarek Helmi
Juhaina Salim Al-Maqbali
Sarah Gamal
Hashim Ba Wazir
Yousuf Al Sulemani
Mohammed Al Za'abi
Source :
Journal of Infection and Public Health, Vol 17, Iss 5, Pp 819-824 (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Background: Antimicrobial resistance is associated with increasing mortality rates and the emergence of multidrug-resistant (MDR) organisms. There is scarcity of data on the short-term impact of Antimicrobial Stewardship Programs (ASP) on antibiotic usage, clinical outcome and MDR organisms’ pattern following the COVID-19 pandemic. This study evaluated the short-term effects of ASP on antibiotic usage, clinical outcomes and MDR organisms’ pattern in the post COVID-19 era. Methods: Conducted at a tertiary academic health center, this observational study involved adult patients (≥18 years) in the general medical unit, treated with oral or intravenous antibiotics from May 1, 2021, to April 30, 2022. The applied ASP strategy was a prospective audit and feedback where a weekly meeting was held to discuss the antimicrobial therapy of admitted patient, after which recommendations were made regarding antimicrobial use. Results: The study included 301 patients with 166 (55.1%) pre-ASP and 135 (44.9%) post-ASP. The median (IQR) age was 69 (55−77) years with 56.1% were female. Antibiotic usage dropped by 25.2% post-ASP. The length of hospital stay (LOS) was longer post-ASP (7 days vs. 7.9 days, p = 0.001), with MDR infections being a significant predictor (OR: 0.486, p

Details

Language :
English
ISSN :
18760341
Volume :
17
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Journal of Infection and Public Health
Publication Type :
Academic Journal
Accession number :
edsdoj.032023fe71404580af29de1d59bf88b6
Document Type :
article
Full Text :
https://doi.org/10.1016/j.jiph.2024.03.013