Back to Search
Start Over
Physical frailty, genetic predisposition, and incident dementia: a large prospective cohort study
- Source :
- Translational Psychiatry, Vol 14, Iss 1, Pp 1-8 (2024)
- Publication Year :
- 2024
- Publisher :
- Nature Publishing Group, 2024.
-
Abstract
- Abstract Physical frailty and genetic factors are both risk factors for increased dementia; nevertheless, the joint effect remains unclear. This study aimed to investigated the long-term relationship between physical frailty, genetic risk, and dementia incidence. A total of 274,194 participants from the UK Biobank were included. We applied Cox proportional hazards regression models to estimate the association between physical frailty and genetic and dementia risks. Among the participants (146,574 females [53.45%]; mean age, 57.24 years), 3,353 (1.22%) new-onset dementia events were recorded. Compared to non-frailty, the hazard ratio (HR) for dementia incidence in prefrailty and frailty was 1.396 (95% confidence interval [CI], 1.294–1.506, P
- Subjects :
- Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Subjects
Details
- Language :
- English
- ISSN :
- 21583188
- Volume :
- 14
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Translational Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.02f56ebedb084e8c864ec7a7115c0e9e
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41398-024-02927-7