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Accelerated infected wound healing by probiotic-based living microneedles with long-acting antibacterial effect

Authors :
Yinli Jin
Yun Lu
Xue Jiang
Min Wang
Yaqi Yuan
Yongnian Zeng
Liang Guo
Wei Li
Source :
Bioactive Materials, Vol 38, Iss , Pp 292-304 (2024)
Publication Year :
2024
Publisher :
KeAi Communications Co., Ltd., 2024.

Abstract

Delays in infected wound healing are usually a result of bacterial infection and local inflammation, which imposes a significant and often underappreciated burden on patients and society. Current therapies for chronic wound infection generally suffer from limited drug permeability and frequent drug administration, owing to the existence of a wound biofilm that acts as a barrier restricting the entry of various antibacterial drugs. Here, we report the design of a biocompatible probiotic-based microneedle (MN) patch that can rapidly deliver beneficial bacteria to wound tissues with improved delivery efficiency. The probiotic is capable of continuously producing antimicrobial substances by metabolizing introduced glycerol, thereby facilitating infected wound healing through long-acting antibacterial and anti-inflammatory effects. Additionally, the beneficial bacteria can remain highly viable (>80 %) inside MNs for as long as 60 days at 4 °C. In a mouse model of Staphylococcus aureus-infected wounds, a single administration of the MN patch exhibited superior antimicrobial efficiency and wound healing performance in comparison with the control groups, indicating great potential for accelerating infected wound closure. Further development of live probiotic-based MN patches may enable patients to better manage chronically infected wounds.

Details

Language :
English
ISSN :
2452199X
Volume :
38
Issue :
292-304
Database :
Directory of Open Access Journals
Journal :
Bioactive Materials
Publication Type :
Academic Journal
Accession number :
edsdoj.02e0d463f4d240a8a3432950fae2ad86
Document Type :
article
Full Text :
https://doi.org/10.1016/j.bioactmat.2024.05.008